tyleroakley:

chadleymacguff:

choctawaukerman:

honestly what the fuck is Kathy Griffin doing w/ her life

truly living it to the fullest

LITERAL QUEEN

I too have this dream

tyleroakley:

chadleymacguff:

choctawaukerman:

honestly what the fuck is Kathy Griffin doing w/ her life

truly living it to the fullest

LITERAL QUEEN

I too have this dream

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birdschoolforbirds:

nah son, i ain’t got no snapchat. I’m old-fashioned. just fax it to me. fax me the nudes.

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durkin62:

watchoutboy:

OH MY GOD WHY, WHY DO YOU DO THIS ON A SITE WITH 13 YEAR OLDS WHO WILL ACTUALLY TRY THIS, STOP

Natural selection.

durkin62:

watchoutboy:

OH MY GOD WHY, WHY DO YOU DO THIS ON A SITE WITH 13 YEAR OLDS WHO WILL ACTUALLY TRY THIS, STOP

Natural selection.

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hinathesexygorilla:

there there now.

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Poor Tanaka, damn that setup was brilliant though.

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coloringpages4kidz:

Love Sailor Moon? Check out anime coloring pages here

coloringpages4kidz:

Love Sailor Moon? Check out anime coloring pages here

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porkmagazine:

WELL I’M UPPER, UPPER CLASS, HIGH SOCIETY. GOD’S GIFT TO BALLROOM NOTORIETY. AND I ALWAYS FILL MY BALLROOM, THE EVENT IS NEVER SMALL, THE SOCIAL PAGES SAY I’VE GOT THE BIGGEST BALLS OF ALL! AND NOW YOU’LL HAVE BIG BALLS AS WELL WITH OUR TANUKI PATCH. THE TANUKI IS A JOVIAL, FUN-LOVING, TRICKSTER YOKAI. A SPIRIT OF THE FOREST & OF INNS & TAVERNS. HE CARRIES A JUG OF WINE AROUND WITH HIM & PAYS FOR HIS DRINKS WITH MONEY THAT TURNS BACK INTO LEAVES WHEN HE LEAVES. RUB MY, I MEAN HIS BALLS FOR GOOD LUCK!!! AT THE PORK SHOP!!! 

WELL SHIT GUESS I GOTTA BUY MORE PATCHES.

porkmagazine:

WELL I’M UPPER, UPPER CLASS, HIGH SOCIETY. GOD’S GIFT TO BALLROOM NOTORIETY. AND I ALWAYS FILL MY BALLROOM, THE EVENT IS NEVER SMALL, THE SOCIAL PAGES SAY I’VE GOT THE BIGGEST BALLS OF ALL! AND NOW YOU’LL HAVE BIG BALLS AS WELL WITH OUR TANUKI PATCH. THE TANUKI IS A JOVIAL, FUN-LOVING, TRICKSTER YOKAI. A SPIRIT OF THE FOREST & OF INNS & TAVERNS. HE CARRIES A JUG OF WINE AROUND WITH HIM & PAYS FOR HIS DRINKS WITH MONEY THAT TURNS BACK INTO LEAVES WHEN HE LEAVES. RUB MY, I MEAN HIS BALLS FOR GOOD LUCK!!! AT THE PORK SHOP!!! 

WELL SHIT GUESS I GOTTA BUY MORE PATCHES.

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scrotumcoat:

jadepurplebrown:

Fruits by Aurel Schmidt

eat a dick

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courtneytrouble:

quilt made from beautiful agony faces (at Museumofsex)

This makes me wanna take up quilting.

courtneytrouble:

quilt made from beautiful agony faces (at Museumofsex)

This makes me wanna take up quilting.

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porkmagazine:

OH WHEN THE MOON SHINES, ON THE COW SHED & WE’RE ROLLIN’ IN THE HAY! ALL THE COWS ARE OUT THERE GRAZIN’ & THE MILK IS ON ITS WAY! I AM A CIDER DRINKER! I DRINKS IT ALL OF THE DAY! I AM A CIDER DRINKER! IT SOOTHES ALL ME TROUBLES AWAY! CIDER DRINKERS! RISE UP & SHOW WHAT’S YOUR FAVORITE!!! OHH ARRR!!! I LOVES IT! BEING A FARMERRRRRRRRRRR……… FOR CIDER PUNKS ESPECIALLY!!! AT THE PORK SHOP!!!

GODDAMNIT THANX PORK I DIDN’T NEED THAT MONEY ANYWAY.

porkmagazine:

OH WHEN THE MOON SHINES, ON THE COW SHED & WE’RE ROLLIN’ IN THE HAY! ALL THE COWS ARE OUT THERE GRAZIN’ & THE MILK IS ON ITS WAY! I AM A CIDER DRINKER! I DRINKS IT ALL OF THE DAY! I AM A CIDER DRINKER! IT SOOTHES ALL ME TROUBLES AWAY! CIDER DRINKERS! RISE UP & SHOW WHAT’S YOUR FAVORITE!!! OHH ARRR!!! I LOVES IT! BEING A FARMERRRRRRRRRRR……… FOR CIDER PUNKS ESPECIALLY!!! AT THE PORK SHOP!!!

GODDAMNIT THANX PORK I DIDN’T NEED THAT MONEY ANYWAY.

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bullied:

i like online shopping and putting everything i want in a cart then checking my subtotal and laughing and closing the tab

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Tiny #werkdoodles post-it, nakie demon hugs.

Tiny #werkdoodles post-it, nakie demon hugs.

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ravennightshade:

thedisreputabledog:

lolitsgabe:

hirotohk:

srawr:

Secret cosplay revealed!  Welcome to Night Vale Miss Frizzle, design by cutie-toes!

:OOOOOO

WHAT



That gif just took it to a whole other level.

ravennightshade:

thedisreputabledog:

lolitsgabe:

hirotohk:

srawr:

Secret cosplay revealed!
Welcome to Night Vale Miss Frizzle, design by cutie-toes!

:OOOOOO

WHAT

image

That gif just took it to a whole other level.

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thescienceofreality:

Engineered vaginas grown in women for the first time by Catherine de Lange | Image Credit: Cliparea/Shutterstock via Science Alert.

Vaginas grown in a lab from the recipients’ own cells have been successfully transferred to the body for the first time.
The surgery was carried out on four women who were born without vaginal canals because of a rare condition. The women, who were teenagers at the time of the operation, now have fully functioning sexual organs.
"After the operation they were able to function normally. They had normal levels of desire, arousal, satisfaction and orgasm," says Anthony Atala at Wake Forest School of Medicine in North Carolina, who led the research. He published the results only after four to eight years had elapsed following surgery, enough time for him to be sure there were no long-term complications.
The four women had undeveloped vaginas because they all have a severe form of a condition called Mayer-Rokitansky-Küster-Hauser Syndrome (MKRH), which affects about 1 in 5000 women. They also had some abnormal development of the uterus, although they did have a vulva – the external part of the sex organ which includes the labia and the clitoris. They were not able to have penetrative sex or menstruate. One of the women was diagnosed after her menstrual blood had collected in her abdomen.
As well as having physical implications, a diagnosis of MKRH is also a huge psychological burden for women.

Maturity challenge
Building on techniques the group developed in the 1990s and perfected on rabbits, Atala and his colleagues removed a small part of the vulva from each woman and grew the cells in the lab. After about four weeks they had enough cells to begin to lay them on to a degradable scaffold one layer at a time “like the layers of a cake”, he says.
The challenge was how to get the cells to grow to the right level of maturity in the lab, says Atala. You need to make sure that the cells are mature enough so that when you implant them into the body, they can recruit other cells in the body to form tissue that includes nerves and blood vessels.
Working with surgeons at the Federico Gomez Children’s Hospital of Mexico in Mexico City, Atala’s team used MRI scans to calculate the appropriate shape and size of the scaffolds for each patient. After cells had established themselves on these scaffolds, surgeons created a cavity in the abdomen and inserted the engineered vagina. It was then stitched in place, connected at the top to the uterus.
The women used a stent for six weeks to make sure the structure maintained the right shape.
The scaffold was made of a collagen matrix and degraded spontaneously over the months following surgery. In that time, the implanted cells matured into the normal tissue of the vaginal wall, including the right layers of muscle and epithelial cells (see video). The vagina was fully developed after six months, and the women were able to menstruate and have sex.
Better than a skin graft
Atala hopes that in the future, the technique could be used to treat not only women who have congenital vaginal defects but also those who have suffered damage through trauma – for instance, because of a car accident or cancer.
Currently it is possible to surgically create vaginas using grafts from either intestinal or skin tissue, but these can lead to severe complications. Skin cell grafts do not provide lubrication which causes pain during sex, and can thicken to the point where the vagina closes. Intestinal cells secrete mucus constantly, which is unhygienic and causes an unpleasant odour. Using the women’s own cells from the vulva gets around these issues.
Knowing that the engineered tissue originates from the recipient’s own body can be reassuring for them, says Sylvie Miot at the University of Basel, Switzerland, whose team has also successfully engineered new nostrils for patients who had to have skin cancers removed from their nose. Their findings are being published in the same issue of the Lancet.
Both studies involved small numbers of patients, but they provide the first strong evidence that nerve and blood vessels can reconnect to large patches of bioengineered tissues directly inside the body.
Normal life
The findings also show that lab-engineered organs can grow to maturity healthily inside the body, says Martin Birchall at University College London. The women were aged between 13 and 18 years old when the surgery took place so their bodies were still developing. Birchall, who pioneered the first transplant of a human windpipe using the recipient’s stem cells, calls the results “very meaningful”.
One of the recipients, who wished to remain anonymous, said the treatment opened up new possibilities. “I truly feel fortunate, because I’ll have a normal life – completely normal,” she says. “It’s important to let other girls that have the same problem know that it does not end knowing that you have the disease, because there is a treatment.”
Two of the four women have a functional uterus, so the big question is whether they will be able to have children. “They haven’t tried,” says Atala, “but they can ovulate, so there is no reason to suspect that they cannot.”
Journal references: The Lancet, DOI: 10.1016/S0140-6736(14)60542-0 and 10.1016/S01460544-4

thescienceofreality:

Engineered vaginas grown in women for the first time by Catherine de Lange | Image Credit: Cliparea/Shutterstock via Science Alert.

Vaginas grown in a lab from the recipients’ own cells have been successfully transferred to the body for the first time.

The surgery was carried out on four women who were born without vaginal canals because of a rare condition. The women, who were teenagers at the time of the operation, now have fully functioning sexual organs.

"After the operation they were able to function normally. They had normal levels of desire, arousal, satisfaction and orgasm," says Anthony Atala at Wake Forest School of Medicine in North Carolina, who led the research. He published the results only after four to eight years had elapsed following surgery, enough time for him to be sure there were no long-term complications.

The four women had undeveloped vaginas because they all have a severe form of a condition called Mayer-Rokitansky-Küster-Hauser Syndrome (MKRH), which affects about 1 in 5000 women. They also had some abnormal development of the uterus, although they did have a vulva – the external part of the sex organ which includes the labia and the clitoris. They were not able to have penetrative sex or menstruate. One of the women was diagnosed after her menstrual blood had collected in her abdomen.

As well as having physical implications, a diagnosis of MKRH is also a huge psychological burden for women.

Maturity challenge

Building on techniques the group developed in the 1990s and perfected on rabbits, Atala and his colleagues removed a small part of the vulva from each woman and grew the cells in the lab. After about four weeks they had enough cells to begin to lay them on to a degradable scaffold one layer at a time “like the layers of a cake”, he says.

The challenge was how to get the cells to grow to the right level of maturity in the lab, says Atala. You need to make sure that the cells are mature enough so that when you implant them into the body, they can recruit other cells in the body to form tissue that includes nerves and blood vessels.

Working with surgeons at the Federico Gomez Children’s Hospital of Mexico in Mexico City, Atala’s team used MRI scans to calculate the appropriate shape and size of the scaffolds for each patient. After cells had established themselves on these scaffolds, surgeons created a cavity in the abdomen and inserted the engineered vagina. It was then stitched in place, connected at the top to the uterus.

The women used a stent for six weeks to make sure the structure maintained the right shape.

The scaffold was made of a collagen matrix and degraded spontaneously over the months following surgery. In that time, the implanted cells matured into the normal tissue of the vaginal wall, including the right layers of muscle and epithelial cells (see video). The vagina was fully developed after six months, and the women were able to menstruate and have sex.

Better than a skin graft

Atala hopes that in the future, the technique could be used to treat not only women who have congenital vaginal defects but also those who have suffered damage through trauma – for instance, because of a car accident or cancer.

Currently it is possible to surgically create vaginas using grafts from either intestinal or skin tissue, but these can lead to severe complications. Skin cell grafts do not provide lubrication which causes pain during sex, and can thicken to the point where the vagina closes. Intestinal cells secrete mucus constantly, which is unhygienic and causes an unpleasant odour. Using the women’s own cells from the vulva gets around these issues.

Knowing that the engineered tissue originates from the recipient’s own body can be reassuring for them, says Sylvie Miot at the University of Basel, Switzerland, whose team has also successfully engineered new nostrils for patients who had to have skin cancers removed from their nose. Their findings are being published in the same issue of the Lancet.

Both studies involved small numbers of patients, but they provide the first strong evidence that nerve and blood vessels can reconnect to large patches of bioengineered tissues directly inside the body.

Normal life

The findings also show that lab-engineered organs can grow to maturity healthily inside the body, says Martin Birchall at University College London. The women were aged between 13 and 18 years old when the surgery took place so their bodies were still developing. Birchall, who pioneered the first transplant of a human windpipe using the recipient’s stem cells, calls the results “very meaningful”.

One of the recipients, who wished to remain anonymous, said the treatment opened up new possibilities. “I truly feel fortunate, because I’ll have a normal life – completely normal,” she says. “It’s important to let other girls that have the same problem know that it does not end knowing that you have the disease, because there is a treatment.”

Two of the four women have a functional uterus, so the big question is whether they will be able to have children. “They haven’t tried,” says Atala, “but they can ovulate, so there is no reason to suspect that they cannot.”

Journal references: The Lancet, DOI: 10.1016/S0140-6736(14)60542-0 and 10.1016/S01460544-4

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